What Happens If Your Platelets Are High – Elevated platelet count, or thrombocytosis, may be a predictor of cancer risk in adults, according to the results of the first large study of its kind published in a journal.
The researchers found that thrombocytosis was present in 11.6% of men and 6.2% of women with cancer – enough numbers to warrant referral to a GP for suspected cancer, according to current National Institute for Health and Care Excellence (NICE) England guidelines. health technology research institute.
What Happens If Your Platelets Are High
The researchers said: “These data exceed the 3% threshold used by NICE for suspected malignancy and suggest that malignancy should be considered in patients with thrombocytosis.”
A) Platelet Count By Age And Sex. Mean Platelet Count, With 1 Sd, In…
They based their findings on statistics from the UK Clinical Practice Survey Datalink, which holds anonymised electronic data on primary care services for around eight per cent. of UK healthcare.
They compared the incidence of cancer in 12 months among 31,261 patients under the age of 40 with thrombocytosis and 7,969 matched groups of patients with platelet counts.
Of the 9,435 men with thrombocytosis, 1,098 were diagnosed with prostate cancer at some point (11.6%; 95% confidence interval [CI] = 11.0-12.3), compared with 106 of 2,599 men. life without thrombocytosis (4.1%; 93.4% CI] — 4.9).
When they focused on female patients, 1,355 of 21,826 patients with thrombocytosis had cancer (6.2%; 95% CI = 5.9-6.5), while 119 of 5,370 women did not have a platelet count (2.2 %; 95% CI = 1.8). — 2.6).
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A second increase in platelet count within six months increased the risk of breast cancer to 18.1% (95% CI = 15.9-20.5) in men and 10.1% (95% CI = 9.0-11.3 ) in women.
As age increases, the incidence of cancer increases and platelet count increases; At least one-third of patients diagnosed with thrombocytotic lung or lung cancer have no symptoms of malignancy.
They said: “This analysis shows that only two-thirds of patients have symptoms that would recommend urgent investigation according to current NICE guidelines; one-third no symptoms other than thrombocytosis in the year before diagnosis.
“In this group, thrombocytosis can be diagnosed early, when other symptoms are not yet present. This suggests that cancer should be considered when there is a manifestation of thrombocytosis, even malignancy was not suspected at first.”
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Chief Health Officer Dr Jasmine Jas said: ‘There are many reasons for a person’s platelet count to be high, and usually it is not cancer.
“It’s not a good idea to measure platelet counts in patients who don’t need a blood test. But if a patient has blood tests for other reasons and the platelet count is high, one of the treatment should be considered if cancer.
“More research is needed to determine whether screening cancer patients based on high platelet counts is life-saving.”
The chair of the Royal College of Physicians, Helen Stokes-Lampard, said the findings were “exciting” additions to existing data on platelet counts.
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He said doctors include platelet levels as part of blood tests done during surgery.
Clinical relevance of thrombocytosis in primary care: a prospective cohort study of cancer incidence using data from the English Electronic Medical Record and Cancer Registry.
Antibiotics can reduce the risk of stomach bleeding from long-term aspirin use, as research has shown that platelet counts, meaning more platelets than normal. Platelets are blood cells that form blood clots. If your platelet count is too high, blood clots can form in your arteries and block blood flow around your body.
A high platelet count can be a sign of an underlying condition. This means that the existing disease causes the body to produce more platelets than it needs.
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This article explains what a high platelet count means, symptoms, tests, consequences, treatment, and more. It also discusses the causes of increased platelets, such as thrombocytosis and thrombocythemia.
Thrombocytes, or platelets, are small blood cells that help blood clot and stop bleeding. Doctors can detect platelet counts with routine blood tests.
A high platelet count indicates an underlying problem. However, it can occur spontaneously, that is, it occurs by itself and not by other diseases. The platelet aggregation poses a health hazard due to the risk of blood clots.
For this reason, doctors divide patients with high platelets into two types of treatment. These are thrombocythemia and thrombocytosis.
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Thrombocytosis, also known as secondary or reactive thrombocytosis, is an increase in platelets that is a symptom of other diseases or damage. It can be the result of anemia, disease or cancer.
Doctors may refer to thrombocythemia as primary or primary thrombocythemia. Scientists believe that this may be the result of gene mutation.
This problem is not common, but it is more common in people aged 50 and 70 years. That said, it can happen at any time. Thrombocythemia is more common in women at birth than in men.
The recommended platelet count in a healthy person is 150,000 to 400,000 platelets per microliter (μL) of blood. Your unique number may change daily.
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The average platelet count in women is about 371,000 per microliter of blood. On average, men have up to 317,000 per microliter of blood.
If your platelet count is above average or more than 400,000 per microliter of blood, it may indicate an underlying disease.
In most cases, high platelets do not cause symptoms. In these cases, doctors only detect high platelets through routine blood tests.
In other cases, increased platelet counts can lead to the development of unnecessary blood clots throughout the body. It can cause many symptoms.
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Thrombocytosis can have different symptoms depending on the underlying disease, disorder, and condition. You may experience the following symptoms.
For example, if your thrombocytosis is caused by anemia, you will first notice some symptoms of red blood cells, such as fatigue.
Because blood clots usually occur in the hands and feet, these symptoms may appear on both hands or feet. However, blood clots can occur anywhere in the body.
If you are older, smoke, have other conditions such as diabetes or high blood pressure, or have a history of blood clots, you may develop blood clots.
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Although not everyone has additional symptoms, some symptoms are severe and pose a serious risk to health and life.
A high platelet count is because the bone marrow produces too many platelets. These platelets can also malfunction and not work as they should.
Doctors are not sure why. However, it is often caused by genetics. When the gene is mutated or changed, it affects how the bone marrow makes platelets, causing thrombocythemia.
Some causes of thrombocytosis cause platelets to increase in the short term during recovery. These reasons may include:
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If you call your doctor about bleeding, clotting, or other symptoms, they may recommend a blood test.
A test called a complete blood count will measure blood cells, including platelets, to determine if your levels are normal.
Your doctor will ask about your medical history and symptoms, as well as family medical history.
Also, after confirming that your platelet count is high, your doctor may refer you to a specialist for further tests or to check the results.
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However, in some cases, medical help is required. Although treatment cannot cure your condition, it can help reduce the risk of blood clots and other serious complications.
Medicines such as aspirin, hydroxyurea, interferon alpha, and anagrelide can be used to treat platelet counts. Aspirin helps prevent blood clots, while other medications lower platelet counts.
Interferon alfa and anagrelide both have serious side effects, so your doctor may recommend aspirin or hydroxyurea first to treat your condition.
Doctors use an IV needle to drain the blood from the vein. The machine then removes the platelets from the blood. Another IV line sends the treated blood back into your body. Doctors use this method only in emergencies.
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Because thrombocytosis is the result of an event or cause, doctors will aim to treat the primary cause of thrombocytopenia as a secondary event.
Doctors can immediately treat the symptoms of thrombocytosis. They will give you medicine to prevent blood clots, reduce platelet count, or treat thrombocytopenia.
High platelets can cause serious illness, so no treatment or poor treatment can lead to serious complications and permanent damage.
When your doctor diagnoses the condition, it is important that you follow it
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